Ipamorelin (acetate) (Synonyms: Aib-His-D-2-Nal-D-Phe-Lys-NH2; NNC 26-0161) |
| Catalog No.GC91449 |
Ipamorelin es un secretagogo de la hormona del crecimiento pentapéptido (GHS) y agonista del receptor GHS 1a (GHS-R1a).
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Ipamorelin is a pentapeptide growth hormone secretagogue (GHS) and GHS receptor 1a (GHS-R1a) agonist.1,2 It binds to COS-7 cells expressing GHS-R1a (Ki = 63.4 nM), induces inositol-1,4,5-triphosphate (IP3) accumulation in BHK cells expressing GHS-R1a (EC50 = 46.9 nM), and induces GH release in primary rat pituitary cells (EC50 = 1.3 nM).1 Ipamorelin increases plasma levels of GH in rats and pigs (ED50s = 80 and 2.3 nmol/kg, respectively) but does not increase plasma levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, or thyroid stimulating hormone (TSH) in pigs when administered at a dose of 420 nmol/kg.2 It increases gastric emptying in a rat model of postoperative ileus induced by laparotomy and intestinal manipulation when administered at doses of 0.014 or 0.14 µmol/kg.3 Ipamorelin (18-450 µg/animal) increases body weight and longitudinal bone growth in rats.4
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