iRucaparib-AP6 |
| Catalog No.GC39191 |
iRucaparib-AP6 es un degradador de PARP1 altamente eficiente y especÍfico basado en Rucaparib utilizando el enfoque PROTAC. iRucaparib-AP6, un degradador de PARP1 que no atrapa, bloquea tanto la actividad catalÍtica como los efectos de andamiaje de PARP1.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2410557-00-3
Sample solution is provided at 25 µL, 10mM.
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iRucaparib-AP6 is a highly efficient and specific PARP1 degrader based on Rucaparib by using thePROTAC approach. iRucaparib-AP6, a non-trapping PARP1 degrader, blocks both the catalytic activity and scaffolding effects of PARP1[1].
[1]. Wang S, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation.Nat Chem Biol. 2019 Dec;15(12):1223-1231.
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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