Isomitraphylline (Synonyms: Ajmalicine Oxindole A) |
| Catalog No.GC91485 |
Isomitraphylline is an alkaloid that has been found in U. tomentosa and has anticancer activity.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 4963-01-3
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Isomitraphylline is an alkaloid that has been found in U. tomentosa and has anticancer activity.[1],[2] It is an antagonist of ecdysteroid receptors in a reporter assay using Drosophila BII cells (EC50 = 160 µM).[1] Isomitraphylline (50 or 100 µM) reduces the proliferation of, and induces apoptosis in, CCRF CEM C7H2 lymphoblastic leukemia cells.[2]
References:
[1].Dinan, L., Bourne, P.C., Meng, Y., et al.Assessment of natural products in the Drosophila melanogaster BII cell bioassay for ecdysteroid agonist and antagonist activitiesCell. Mol. Life Sci.58(2)321-342(2001).
[2].Bacher, N., Tienfenthaler, M., Sturm, S., et al.Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cellsBr. J. Haematol.132(5)615-622(2006).
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *