JWH 203 N-(5-hydroxypentyl) metabolite-d5

JWH 203 N-(5-hydroxypentyl) metabolite-d₅ contains five deuterium atoms at the 2, 4, 5, 6, and 7 positions. It is intended for use as an internal standard for the quantification of JWH 203 N-(5-hydroxypentyl) metabolite by GC- or LC-mass spectrometry. JWH 203 is an analgesic chemical from the phenylacetylindole family that acts as a cannabinoid (CB) agonist with K_i values of 8.0 and 7.0 nM at the central (CB₁) and peripheral (CB₂) receptors, respectively.¹ Similar to the related 2'-methoxy compound JWH 250 , JWH 203 has a phenylacetyl group in place of the naphthoyl ring used in most aminoalkylindole CB compounds. Compared to JWH 250, JWH 203 displays slightly more potent binding affinities for the CB₁ and CB₂ CB receptors (JWH 250 K_is = 11 and 33 nM, respectively).¹ JWH 203 N-(5-hydroxypentyl) metabolite is expected to be a metabolite of JWH 203 that would be detectable both in serum and in urine.

1.Huffman, J.W., Szklennik, P.V., Almond, A., et al.1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indolesBioorg. Med. Chem. Lett.15(18)4110-4113(2005)