K-Ras ligand-Linker Conjugate 6 |
| Catalog No.GC39714 |
El ligando K-Ras-enlazador conjugado 6 incorpora un ligando para la fracciÓn de reclutamiento de K-Ras y un enlazador PROTAC, que recluta ligasas E3 (como VHL, CRBN, MDM2 e IAP). El conjugado 6 de ligando-ligando de K-Ras se puede utilizar en la sÍntesis de PROTAC K-Ras Degrader-1, que es un potente degradador de PROTAC K-Ras que presenta una eficacia de degradaciÓn ≥70 % en células SW1573.
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Cas No.: 2378261-89-1
Sample solution is provided at 25 µL, 10mM.
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K-Ras ligand-Linker Conjugate 6 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 6 can be used in the synthesis of PROTAC K-Ras Degrader-1 , which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].
[1]. CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2.
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