KAT8 Inhibitor 19 (Synonyms: Lysine Acetyltransferase 8 Inhibitor 19) |
Catalog No.GC91622 |
KAT8 inhibitor 19 is an inhibitor of lysine acetyltransferase 8 (KAT8; IC50 = 12.1 µM).
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Cas No.: 28532-21-0
Sample solution is provided at 25 µL, 10mM.
KAT8 inhibitor 19 is an inhibitor of lysine acetyltransferase 8 (KAT8; IC50 = 12.1 µM).[1] It is selective for KAT8 over KAT2A, KAT2B, KAT3B, KAT6A, and KAT7 at 200 µM. KAT8 (50 µM) reduces histone 4 lysine 16 acetylation (H4K16Ac) in HT-29 colorectal carcinoma cells. It reduces the viability of HCT116, H1299, A549, and U937 cancer cells (IC50s = 39.4, 52.1, 41, and 30.1 µM, respectively).
References:
[1].Fiorentino, F., Sementilli, S., Menna, M., et al.First-in-class selective inhibitors of the lysine acetyltransferase KAT8J. Med. Chem.66(10)6591-6616(2023).
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