KYL (trifluoroacetate salt) (Synonyms: KYL Peptide) |
| Catalog No.GC52328 |
An EphA4 inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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KYL is a 12-amino acid synthetic peptide and an inhibitor of the Eph tyrosine kinase receptor A4 (EphA4; IC50 = 4.22 µM).1 KYL inhibits EphA4-induced growth cone collapse in embryonic chicken retina explants when used at a concentration of 5 µM.2
1.Wu, B., Zhang, Z., Noberini, R., et al.HTS by NMR of combinatorial libraries: A fragment-based approach to ligand discoveryChem. Biol.20(1)19-33(2013) 2.Noberini, R., Koolpe, M., Peddibhotla, S., et al.Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptorsJ. Biol. Chem.283(43)29461-29472(2008)
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