L-Homopropargylglycine hydrochloride (Synonyms: HPG) |
| Catalog No.GC63043 |
El clorhidrato de L-homopropargilglicina es un conector PROTAC basado en una cadena de alquilo que se puede utilizar en la sÍntesis de PROTAC. El clorhidrato de L-homopropargilglicina es un anÁlogo de aminoÁcido de la metionina que contiene un resto alquino que puede sufrir una reacciÓn quÍmica de clic clÁsica con azida que contiene Alexa Fluor.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 942518-19-6
Sample solution is provided at 25 µL, 10mM.
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L-Homopropargylglycine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-homopropargylglycine hydrochloride is an amino acid analog of methionine containing an alkyne moiety that can undergo a classic click chemical reaction with azide containing Alexa Fluor[1][2].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018;36:553-562.
[2]. Shen Y, et al. Protocol for visualizing newly synthesized proteins in primary mouse hepatocytes. STAR Protoc. 2021;2(3):100616. Published 2021 Jun 17.
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