Ly93 |
| Catalog No.GC64957 |
Ly93 es un inhibidor de la esfingomielina sintasa 2 (SMS2) selectivo y activo por vÍa oral, con una IC50 de 91 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1883528-69-5
Sample solution is provided at 25 µL, 10mM.
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Ly93 is a selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with an IC50 of 91 nM[1].
Ly93 (100 mg/kg, i.g. once daily for 7 days) significantly decreases the plasma SM levels of C57BL/6J mice[1].Ly93 dose-dependently attenuates the atherosclerotic lesions in the root and the entire aorta as well as macrophage content in lesions, in apolipoprotein E gene knockout mice[1].
[1]. Li Y, et al. Discovery, synthesis and anti-atherosclerotic activities of a novel selective sphingomyelin synthase 2 inhibitor. Eur J Med Chem. 2019 Feb 1;163:864-882.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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