Marinobufagenin (Synonyms: Marinobufagin, MBG, NSC 234205) |
| Catalog No.GC18189 |
La marinobufagenina es un potente inhibidor de la Na+/K+ ATPasa que se ha identificado en el plasma de los mamÍferos.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 470-42-8
Sample solution is provided at 25 µL, 10mM.
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Marinobufagenin (MBG) is a bufadienolide steroid first isolated from toads of genus Bufo. It can also be excreted by mammalian cells, particularly kidney cells from hypertensive animals. MBG inhibits the ouabain-resistant α1 Na+/K+ ATPase subunit (IC50 = 78 nM), impairing a major sodium pump of the kidneys, resulting in natriuresis and arterial hypertension. Serum and urine levels of MBG are also elevated after cardiac infarction, and a reduced form of MBG, marinobufotoxin, occurs in the plasma of patients with terminal renal failure. Through its effects on the α1 Na+/K+ ATPase subunit, MBG has profound immediate and prolonged effects on kidney, heart, and vascular functions.
Review for Marinobufagenin
Average Rating: 5 (Based on Reviews and 14 reference(s) in Google Scholar.)
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