ML 348 (Synonyms: CID 3238952, SID 160654487) |
| Catalog No.GC18039 |
ML 348 (GNF-Pf-1127) es un inhibidor selectivo y reversible de la acil-proteína tioesterasa 1 (APT1)/lisofosfolipasa 1 (LYPLA1) con una IC50 de 210 nM y apenas inhibe a LYPLA2.
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Cas No.: 899713-86-1
Sample solution is provided at 25 µL, 10mM.
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ML348 is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor with an IC50 of 210 nM, and barely inhibits LYPLA2[1].
ML348 (5 µM; 3 hours ) selectively inhibits LYPLA1 in cultured cells[1].
ML348 (50 mg/kg, i.p., 3 hours) shows potent and selective activity in vivo, inhibits LYPLA1 enzymes in heart, kidney and lung in mice[1].
References:
[1]. Adibekian A et al. Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 1 (LYPLA1). National Center for Biotechnology Information (US); 2010- 2013 Apr 08.
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