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N-Arachidonoyl Dopamine (Synonyms: NADA)

Catalog No.GC18506

La N-araquidonoil dopamina es un agonista del receptor CB1 endÓgeno potente y selectivo con una Ki de 250 nM.

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N-Arachidonoyl Dopamine Chemical Structure

Cas No.: 199875-69-9

Tamaño Precio Disponibilidad Cantidad
1mg
44,00 $
Disponible
5mg
101,00 $
Disponible
10mg
154,00 $
Disponible
25mg
261,00 $
Disponible
50mg
388,00 $
Disponible

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Sample solution is provided at 25 µL, 10mM.

Description of N-Arachidonoyl Dopamine

Several different arachidonoyl amino acids, including N-arachidonoyl dopamine (NADA), have been isolated and characterized from bovine brain. NADA is the amide of the neurotransmitter dopamine and arachidonic acid. NADA is a CB1-selective agonist, inducing the typical tetrad of hypothermia, analgesia, catalepsy, and hypomotility in rats which exceeds that of anandamide (AEA). NADA is a full agonist at the vanilloid receptor 1, but is inactive on the dopaminergic D1 and D2 receptors. NADA is also a potent inhibitor (IC50 = 0.25 uM) of the proliferation of MCF-7 breast carcinoma cells. Recent reports of NADA’s endothelium-dependent vasodilation indicate that some of its cannabinergic activities antagonized by SR141716A may be non-CB1/CB2 dependent.

Chemical Properties of N-Arachidonoyl Dopamine

Cas No. 199875-69-9 SDF
Sinónimos NADA
Chemical Name N-[2-(3,4-dihydroxyphenyl)ethyl]-5Z,8Z,11Z,14Z-eicosatetraenamide
Canonical SMILES CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCCc1ccc(O)c(O)c1
Formula C28H41NO3 M.Wt 439.6
Solubility 0.1 M Na2CO3: Colloidal suspension @ <100 µ g,DMF: Miscible,DMSO: Miscible,Ethanol: Miscible,Ethanol:PBS (1:1): 100 µ g/ml (colloidal suspensio Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of N-Arachidonoyl Dopamine

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1 mg 5 mg 10 mg
1 mM 2.2748 mL 11.374 mL 22.748 mL
5 mM 0.455 mL 2.2748 mL 4.5496 mL
10 mM 0.2275 mL 1.1374 mL 2.2748 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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3. All of the above co-solvents are available for purchase on the GlpBio website.

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