N-Descyclopropanecarbaldehyde Olaparib |
Catalog No.GC62154 |
N-desciclopropanocarbaldehÍdo Olaparib es un anÁlogo de Olaparib que contiene un resto DOTA. N-DesciclopropanocarbaldehÍdo Olaparib es un ligando basado en CRBN para sintetizar nuevos EGFR duales y PARP PROTAC, DP-C-4. N-desciclopropanocarbaldehÍdo Olaparib puede ser radiomarcado F-18 o fluorÓforo para tomografÍa por emisiÓn de positrones (PET) o imÁgenes Ópticas en varios tipos de tumores.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 763111-47-3
Sample solution is provided at 25 µL, 10mM.
N-Descyclopropanecarbaldehyde Olaparib is an analogue of Olaparib containing DOTA moiety. N-Descyclopropanecarbaldehyde Olaparib is a CRBN-based ligand for synthesizing novel dual EGFR and PARP PROTAC, DP-C-4[1]. N-Descyclopropanecarbaldehyde Olaparib can be radiolabeled F-18 or fluorophore for positron emission tomography (PET) or optical imaging in several types of tumor[2].
[1]. Tao Huang, et al. Initial evaluation of Cu-64 labeled PARPi-DOTA PET imaging in mice with mesothelioma. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3472-3476.
[2]. Mengzhu Zheng, et al. Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP. J Med Chem. 2021 May 26.
Average Rating: 5
(Based on Reviews and 5 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *