NADP+ (hydrate) (Synonyms: Coenzyme II, β-NADP, Nicotinamide adenine dinucleotide phosphate, TPN)

NADP⁺ is the oxidized form of the electron donor nicotinamide adenine dinucleotide phosphate . It serves as a cofactor in various biological reactions.^1,2 In addition, the balance between these reduced and oxidized forms plays key roles in diverse cellular functions, including cell survival, the maintenance of redox status, and intracellular signaling.^2,3 For example, binding of NADP⁺ to β-subunits of K_v channels activates ion transport, whereas NADPH stabilizes channel inactivation.⁴ NADP⁺ is biosynthesized from NAD⁺ by NAD kinase, with ATP as the phosphoryl donor.⁵

1.Jackson, J.B.A review of the binding-change mechanism for proton-translocating transhydrogenaseBiochimica et Biophysica Acta1817(10)1839-1846(2012) 2.Nakamura, M., Bhatnagar, A., and Sadoshima, J.Overview of pyridine nucleotides review seriesCirc. Res.111(5)604-610(2012) 3.Ziegler, M.A vital link between energy and signal transduction: Regulatory functions of NAD(P)FEBS Journal272(18)4561-4564(2014) 4.Kilfoil, P.J., Tipparaju, S.M., Barski, O.A., et al.Regulation of ion channels by pyridine nucleotidesCirc. Res.112(4)721-741(2013) 5.Shi, F., Li, Y., Li, Y., et al.Molecular properties, functions, and potential applications of NAD kinasesActa Biochim. Biophys. Sin. (Shanghai)41(5)352-361(2009)