NGI-1 (ML414) (Synonyms: N-linked Glycosylation Inhibitor 1) |
| Catalog No.GC33055 |
NGI-1 (ML414) (ML414) es un potente inhibidor de la oligosacariltransferasa (OST), que se dirige directamente y bloquea la funciÓn de las subunidades catalÍticas de la OST STT3A y STT3B. NGI-1 (ML414) es un inhibidor permeable a las células y puede reducir eficazmente la infectividad del virus sin afectar la viabilidad celular.
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Cas No.: 790702-57-7
Sample solution is provided at 25 µL, 10mM.
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NGI-1 is a cell permeable inhibitor.
NGI-1 blocks EGFR N-linked glycosylation in lung adenocarcinoma cells as assessed. In controls EGFR is biotinylated, consistent with its plasma membrane expression, but in NGI-1 treated cells the EGFR is predominantly found in the non-biotinylated intracellular fraction suggesting a change in cellular localization[1].
[1]. Lopez-Sambrooks C, et al. Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nat Chem Biol. 2016 Dec;12(12):1023-1030.
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