NH2-PEG9-acid |
| Catalog No.GC61969 |
NH2-PEG9-Ácido es un enlazador ADC de PEG de 9 unidades no escindible que se utiliza en la sÍntesis de conjugados de anticuerpo-fÁrmaco (ADC). El Ácido NH2-PEG9 también es un conector PROTAC basado en PEG que se puede utilizar en la sÍntesis de PROTAC.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 756526-04-2
Sample solution is provided at 25 µL, 10mM.
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NH2-PEG9-acid is a non-cleavable 9 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. NH2-PEG9-acid also is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
[1]. Michael Nathaniel ALONSO, et al. Antibody adjuvant conjugates. WO2018009916A1.
[2]. "An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562."
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)
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