NIC-0102 |
| Catalog No.GC71149 |
NIC-0102 es un inhibidor de proteosoma activo por vía oral (pIC50=7.55) que inhiespecíficamente la activación de la vesícula inflamnlrp3.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2806031-94-5
Sample solution is provided at 25 µL, 10mM.
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NIC-0102 (compound 27) (7.5, 15, 30, 60 nM; 1h) specifically suppresses NLRP3 inflammasome activation in LPS-primed J774A.1 and BMDM cells[1].
NIC-0102 (7.5, 15, 30, 60 nM; 1h) induces polyubiquitination of NLRP3 via inhibition of the proteasome during the activation step in LPS-primed J774A.1 cells[1].
NIC-0102 (7.5, 15, 30, 60 nM; 1h) exhibits inhibitory effects on NF-κB in the priming step of the NLRP3 pathway in LPS-primed J774A.1 cells[1].
NIC-0102 (15, 60 nM; 1h) blocks NLRP3-ASC interaction and ASC oligomerization in LPS-primed J774A.1 cells[1].
NIC-0102 (0.125, 0.25, 0.5 mg/kg; p.o.; single every 72 h for 10 days) shows strong protection against DSS-induced acute colitis in mice[1].
References:
[1]. Wu X, et al. Discovery of a Novel Oral Proteasome Inhibitor to Block NLRP3 Inflammasome Activation with Anti-inflammation Activity. J Med Chem. 2022 Sep 5.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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