Nonactin, Monactin, and Dinactin Mixture |
Catalog No.GC91451 |
La mezcla de nonactina, monactina y dinactina es un antibiótico macrotetralídico.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
Nonactin, monactin, and dinactin mixture is a macrotetralide antibiotic.1 This product is a mixture of the macrotetralide antibiotic homologs nonactin, monactin , and dinactin that all act as ionophores for monovalent cations.2,3,4,5,6,7 Nonactin is a mitochondrial membrane uncoupler and an inhibitor of adenine nucleotide translocase (ANT; IC50s = 4.4, 3.3, 4.7, and 3.3 µM for recombinant human ANT1-4, respectively).8,9 It selectively induces apoptosis in cancer cells and induces tumor regression in mouse xenograft models expressing mutant β-catenin over cancer cells and xenografts expressing wild-type β-catenin.8 Monactin induces swelling of rat liver mitochondria in medium containing either potassium or sodium, stimulates respiration, and uncouples oxidative phosphorylation.10 It also inhibits Wnt signaling via inhibition of TCF-β-catenin transcriptional activity.11 Dinactin inhibits T cell proliferation and cytokine production in vitro and reduces pulmonary eosinophilia in antigen-challenged mice.12
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(Based on Reviews and 30 reference(s) in Google Scholar.)Review for Nonactin, Monactin, and Dinactin Mixture
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