Oleoyl Serotonin-d17

Oleoyl serotonin-d₁₇ contains 17 deuterium atoms at the 11, 11', 12, 12', 13, 13', 14, 14', 15, 15', 16, 16', 17, 17', 18, 18, and 18 positions. It is intended for use as an internal standard for the quantification of oleoyl serotonin by GC- or LC-mass spectrometry. Oleoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin . Arachidonoyl serotonin is a dual antagonist of fatty acid amide hydrolase (FAAH) and the transient receptor potential vanilloid-type 1 (TRPV1) channel, reducing both acute and chronic peripheral pain.^1,2 Oleoyl Serotonin inhibits capsaicin-induced TRPV1 channel activation (IC₅₀ = 2.57 μM) without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamine (IC₅₀ > 50 μM).¹

1.Ortar, G., Cascio, M.G., De Petrocellis, L., et al.New N-arachidonoylserotonin analogues with potential "dual" mechanism of action against painJournal of Medicinal Chemistry506554-6569(2007) 2.Maione, S., De Petrocellis, L., de Novellis, V., et al.Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptorsBritish Journal of Pharmacology150766-781(2007)