ON-013100 |
| Catalog No.GC33353 |
ON-013100, un fÁrmaco antineoplÁsico, actÚa como inhibidor mitÓtico que podrÍa inhibir la expresiÓn de la ciclina D1.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 865783-95-5
Sample solution is provided at 25 µL, 10mM.
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ON-013100, an antineoplastic drug, acts a mitotic inhibitor that could inhibit Cyclin D1 expression.
ON-013100 induces apoptosis, and has activity against most human cancer cell lines in vitro [1]. Cho SY, et al. Determination of the glucuronide metabolite of ON 013100, a benzylstyrylsulfone antineoplastic drug, in colon cancer cells using LC/MS/MS. J Pharm Biomed Anal. 2013 Mar 5;75:138-44. [2]. Park IW, et al. Evaluation of novel cell cycle inhibitors in mantle cell lymphoma. Oncogene. 2007 Aug 16;26(38):5635-42. [3]. Neel Jasani, et al. Potent anticancer activity of an orally bioavailable small molecule, ON 013100, and its water soluble derivative, briciclib, a clinical-stage eIF4E-targeted agent. AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA.
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)
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