Ouabain-d3 (Synonyms: g-Strophanthin-d3) |
| Catalog No.GC91439 |
Ouabain-d3 está destinado para su uso como estándar interno en la cuantificación de ouabaina por GC- o LC-MS.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Ouabain-d3 is intended for use as an internal standard for the quantification of ouabain by GC- or LC-MS. Ouabain is a cardiac glycoside that has been found in S. gratus and has diverse biological activities.1,2,3,4,5,6,7 It inhibits the Na+/K+-ATPase isoforms α1β1 and α2β1 and human-ether-a-go-go (hERG), also known as Kv11.1 (IC50s = 97, 90, and 15.2 nM, respectively).2,3 Ouabain reduces the proliferation of PC3 prostate cancer and U937 lymphoma cells (EC50s = 210 and 94 nM, respectively).4 It inhibits the cytopathic effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in infected Vero cells (IC50 = 5 Ouabain (~8 µg/animal) increases systolic blood pressure in normotensive rats.6 It has been used to induce ventricular arrythmias in vivo.7 Formulations containing ouabain have been used in the treatment of atrial fibrillation, atrial flutter, and heart failure.
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Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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