PCSK9 degrader 1 |
| Catalog No.GC70635 |
PCSK9 degrader 1 (compuesto 16) es un ligando de molécula pequeña para la proproteína convertasa tipo sustilisina /kexin tipo 9 (PCSK9) y muestra alta afincon PCSK9 con un Ki de 107 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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PCSK9 degrader 1 (Compound 16; 1.25-20 μM; 24 hours; HEK293 cells) treatment shows a clear concentration-dependent degradation of both the pro and mature form of PCSK9 yielding a half-maximal degradation concentration of 4.8 and 3.4 μM, as well as a maximum percentage of degradation at 20 μM of 58% and 61%, respectively[1].
References:
[1]. Petrilli WL, et al. From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9. Cell Chem Biol. 2019 Oct 22. pii: S2451-9456(19)30322-8.
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