Pom-8PEG |
| Catalog No.GC63149 |
Pom-8PEG, un conjugado enlazador-ligando de ligasa E3, incorpora un ligando cereblon (CRBN) para la ubiquitina ligasa E3 y un enlazador PEG de 8 unidades. Pom-8PEG se puede utilizar en la sÍntesis de PROTAC, como el degradador IDO1 PROTAC.
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Cas No.: 2488761-03-9
Sample solution is provided at 25 µL, 10mM.
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Pom-8PEG, an E3 ligase ligand-linker conjugate, incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase and an 8-unit PEG linker. Pom-8PEG can be used in the synthesis of PROTAC, such as IDO1 PROTAC degrader[1].
[1]. Hu M, et al. Discovery of the first potent proteolysis targeting chimera (PROTAC) degrader of indoleamine 2,3-dioxygenase 1. Acta Pharm Sin B. 2020;10(10):1943-1953.
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