Pomalidomide-PEG1-C2-N3 (Synonyms: Cereblon Ligand-Linker Conjugates 13; E3 ligase Ligand-Linker Conjugates 50) |
| Catalog No.GC61200 |
Pomalidomida-PEG1-C2-N3 es un conjugado ligando-enlazador de ligasa E3 sintetizado que incorpora el ligando cereblon basado en pomalidomida y el enlazador PEG de 1 unidad utilizado en la tecnologÍa PROTAC. Pomalidomida-PEG1-C2-N3 se puede utilizar para diseÑar un degradador selectivo CDK6 PROTAC CP-10. CP-10 induce la degradaciÓn de CDK6 con un DC50 de 2,1 nM.
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Cas No.: 2271036-44-1
Sample solution is provided at 25 µL, 10mM.
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Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC50 of 2.1 nM[1].
[1]. Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 2.
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