Pomalidomide-PEG6-butyl iodide |
| Catalog No.GC65196 |
Pomalidomida-PEG6-yoduro de butilo es un conjugado de enlazador-ligando de ligasa E3 sintetizado que incorpora el ligando de cereblon basado en pomalidomida y el enlazador de PEG de 6 unidades utilizado en la tecnologÍa PROTAC.
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Cas No.: 1835705-74-2
Sample solution is provided at 25 µL, 10mM.
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Pomalidomide-PEG6-butyl iodide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 6-unit PEG linker used in PROTAC technology[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. Lai AC, et al. Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL. Angew Chem Int Ed Engl. 2016 Jan 11;55(2):807-10.
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