Procarbazine HCl (Synonyms: Indicarb, Natulan, NSC 77213) |
Catalog No.GC11793 |
El clorhidrato de procarbazina es un agente alquilante activo por vÍa oral, con actividad anticancerÍgena. Procarbazine HCl se puede utilizar en la investigaciÓn de la enfermedad de Hodgkin's.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 366-70-1
Sample solution is provided at 25 µL, 10mM.
Procarbazine Hydrochloride is an alkylating agent, with anticancer activity.
Procarbazine Hydrochloride is an anticancer agent. Procarbazine is not cytotoxic to the LI 210 cells which lack cytochrome P-450 or monoamine oxidase activity[1].
Procarbazine Hydrochloride (50 mg/kg, i.p.) causes micronuclei in hematopoietic cells, but does not increase the lacZ mutant frequency (MF) in bone marrow of mice, similar to that in liver, testis, spleen, kidney, and lung. Procarbazine Hydrochloride (50 mg/kg, i.p.) has positive effect on lung, bone marrow, and spleen for carcinogenesis[2]. Procarbazine (450 mg/kg) significantly decreases testicular and epididymal weight and drastically reduces haploid cells and spermatogenic arrest in hamster[3].
References:
[1]. Erikson JM, et al. Cytotoxicity and DNA damage caused by the azoxy metabolites of procarbazine in L1210 tumor cells. Cancer Res. 1989 Jan 1;49(1):127-33.
[2]. Suzuki T, et al. Procarbazine genotoxicity in the MutaMouse; strong clastogenicity and organ-specific induction of lacZ mutations. Mutat Res. 1999 Aug 18;444(2):269-81.
[3]. Weissenberg R, et al. Procarbazine effects on spermatogenesis in golden hamster: a flow cytometric evaluation. Arch Androl. 2002 Mar-Apr;48(2):91-100.
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