Propargyl-PEG4-Br |
| Catalog No.GC62245 |
Propargyl-PEG4-Br es un conector PROTAC basado en PEG que se puede utilizar en la sÍntesis de PROTAC. Propargyl-PEG4-Br es un conector ADC no escindible que se utiliza en la sÍntesis de conjugados de anticuerpo y fÁrmaco (ADC).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1308299-09-3
Sample solution is provided at 25 µL, 10mM.
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Propargyl-PEG4-Br is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-Br is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
[1]. Suzanne AKERS-RODRIGUEZ, et al. Compositions and methods for the treatment of bacterial infections. WO2019126353A2.
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