Propargyl-PEG6-acid |
| Catalog No.GC65653 |
Propargyl-PEG6-acid es un conector PROTAC basado en PEG que se puede utilizar en la sÍntesis de PROTAC. Propargyl-PEG6-acid es un enlazador de ADC escindible que se utiliza en la sÍntesis de conjugados de anticuerpo-fÁrmaco (ADC).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1951438-84-8
Sample solution is provided at 25 µL, 10mM.
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Propargyl-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG6-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
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