Propargyl-PEG8-NHS ester |
| Catalog No.GC66707 |
Propargyl-PEG8-NHS éster es un enlazador PROTAC basado en PEG/Alkyl/ether que se puede utilizar en la síntesis de PROTAC. Propargyl-PEG8-NHS éster es un enlazador de ADC escindible que se utiliza en la síntesis de conjugados de anticuerpo-fármaco (ADC).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2182601-74-5
Sample solution is provided at 25 µL, 10mM.
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Propargyl-PEG8-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG8-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
[1]. Satwik Kamtekar, et al. Modified biotin-binding proteins for immobilization. WO2019126734A1.
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