PROTAC HSP90 degrader BP3 |
| Catalog No.GC64825 |
El degradador BP3 de PROTAC HSP90 es una degradaciÓn potente y selectiva de HSP90 de forma dependiente de CRBN. El degradador BP3 de PROTAC HSP90 tiene cierto efecto de degradaciÓn sobre la proteÍna HSP90 en células MCF-7 (DC50=0,99 μM). PROTAC HSP90 degradador BP3 inhibe el crecimiento de células de cÁncer de mama.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2669072-88-0
Sample solution is provided at 25 µL, 10mM.
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PROTAC HSP90 degrader BP3 is a potent and selective degradation of HSP90 in a CRBN-dependent fashion. PROTAC HSP90 degrader BP3 has a certain certain degradation effect on HSP90 protein in MCF-7 cells (DC50=0.99 µM). PROTAC HSP90 degrader BP3 inhibits the growth of breast cancer cell[1].
PROTAC HSP90 degrader BP3 (compound 16b) (72 h) inhibits the growth of breast cancer cells (IC50=0.63 µM in MCF-7 cells, IC50=3.53 µM in MDA-MB-231 cells, IC50=0.61 µM in 4T1 cells, IC50=2.95 µM in MDA-MB-468 cells)[1].PROTAC HSP90 degrader BP3 (2 µM; 6 h) shows degradation activity in the MCF-7 cells (DC50=0.99 µM)[1].
PROTAC HSP90 degrader BP3 (40 mg/kg; i.p., daily for 12 days) inhibits tumor growth and the tumor inhibition rate is 76.41%[1].
[1]. Liu Q, et al. Discovery of BP3 as an efficacious proteolysis targeting chimera (PROTAC) degrader of HSP90 for treating breast cancer. Eur J Med Chem. 2022, 228:114013.
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