PROTAC Sirt2-binding moiety 1 (Synonyms: PROTAC Sirt2-binding moiety 1) |
| Catalog No.GC34741 |
El resto 1 de uniÓn a Sirt2 de PROTAC es un inhibidor selectivo y muy potente de Sirtuin 2 (Sirt2), con una IC50 de 2,4 μM. El resto 1 de uniÓn a PROTAC Sirt2, el resto basado en SirReal1, se une al ligando de cereblon a través de un enlazador para formar PROTAC y degradar Sirt2.
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Cas No.: 1862237-99-7
Sample solution is provided at 25 µL, 10mM.
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PROTAC Sirt2-binding moiety 1 is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. For the development of sirtuin rearranging ligands (SirReals)-based PROTAC[1]. IC50: 2.4 μM (Sirt2)[1].
[1]. Schiedel M, et al. Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). J Med Chem. 2018 Jan 25;61(2):482-491.
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