Pseudoprotodioscin |
| Catalog No.GC38839 |
La pseudoprotodioscina, un furostanÓsido, inhibe los niveles de SREBP1/2 y microARN 33a/b y reduce la expresiÓn de genes relacionados con la sÍntesis de colesterol y triglicéridos.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 102115-79-7
Sample solution is provided at 25 µL, 10mM.
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Pseudoprotodioscin, a furostanoside, inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides[1].
In Hep G2 cells, Pseudoprotodioscin increases ABCA1 protein and mRNA levels, and promotes the effluxion of ApoA-1-mediated cholesterol. Pseudoprotodioscin inhibits SREBP1c and SREBP2 transcription by decreasing microRNA 33a/b levels. This procedure reciprocally lead to the increase of ABCA1 levels. In THP-1 macrophages, Pseudoprotodioscin shows the similar effect, which reduces HMGCR, FAS and ACC mRNA levels and promotes low density lipoprotein receptor by decreasing the PCSK9 levels[1].
[1]. Gai Y, et al. Pseudoprotodioscin inhibits SREBPs and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides. Fitoterapia. 2019 Nov;139:104393. [2]. Liang ZZ, et al. Oligofurostanosides from Asparagus cochinchinensis. Planta Med. 1988 Aug;54(4):344-6.
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