QM31 (Synonyms: SVT016426) |
| Catalog No.GC65474 |
QM31 (SVT016426), un agente citoprotector, es un inhibidor selectivo de Apaf-1. QM31 inhibe la formaciÓn del apoptosoma (IC50=7.9μM), el complejo de activaciÓn de caspasa compuesto por Apaf-1, citocromo c, dATP y caspasa-9. QM31 ejerce funciones mitocondrioprotectoras e interfiere con el punto de control de daÑos en el ADN dentro de la fase S.
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Cas No.: 937735-00-7
Sample solution is provided at 25 µL, 10mM.
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QM31 (SVT016426), a cytoprotective agent, is a selective inhibitor of Apaf-1. QM31 inhibits the formation of the apoptosome (IC50=7.9μM), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9. QM31 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint[1][2].
SVT016426 (0.5-2 μM) inhibits Apaf1-induced activation of caspase activity with an IC50 of 5 μM in HeLa S100 cells[3].
[1]. MondragÓn L, et al. A chemical inhibitor of Apaf-1 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint. Apoptosis. 2009 Feb;14(2):182-90.
[2]. OrzÁez M, et al. Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity. PLoS One. 2014 Oct 20;9(10):e110979.
[3]. Gortat A, et al. Apaf1 inhibition promotes cell recovery from apoptosis. Protein Cell. 2015 Nov;6(11):833-43.
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