RB-3 |
| Catalog No.GC65605 |
RB-3, un inhibidor de PRC1, se une a RING1B-BMI1f, con una Kd de 2,8 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2396639-11-3
Sample solution is provided at 25 µL, 10mM.
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RB-3, a PRC1 inhibitor, binds to RING1B-BMI1f, with a Kd of 2.8 μM[1].
RB-3 decreases the global level of H2A ubiquitination and induces differentiation in leukemia cell lines and primary acute myeloid leukemia (AML) samples[1].RB-3 inhibits H2A ubiquitination with an IC50 of 1.6 μM[1].RB-3 inhibits PRC1 and disrupts the interaction with nucleosomes[1].RB-3 reduces colony formation in a mixed lineage leukemia (MLL)-eleven nineteen leukemia (ENL) model[1].
[1]. Shirish Shukla, et al. Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain. Nat Chem Biol. 2021 Jul;17(7):784-793.
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