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ABC99

Catalog No.GC42669

ABC99 es un carbamato de N-hidroxihidantoÍna (NHH) que inhibe selectivamente la enzima NOTUM desacilante de Wnt (IC50=13 nM). ABC99 conserva la seÑalizaciÓn Wnt3A en presencia de NOTUM.

Products are for research use only. Not for human use. We do not sell to patients.

ABC99 Chemical Structure

Cas No.: 2331255-53-7

Tamaño Precio Disponibilidad Cantidad
500ug
114,00 $
Disponible
1mg
215,00 $
Disponible
5mg
782,00 $
Disponible

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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 3 publications

Description Chemical Properties Product Documents Related Products

ABC99 is an N-hydroxyhydantoin (NHH) carbamate that inhibits the Wnt-deacylating enzyme NOTUM (IC50 = 13 nM).[1] It preserves Wnt3A signaling in the presence of NOTUM (EC50 = 89 nM in a cell-based reporter assay).

Reference:
[1]. Suciu, R.M., Cognetta, A.B., III., Potter, Z.E., et al. Selective irreversible inhibitors of the Wnt-deacylating enzyme NOTUM developed by activity-based protein profiling. ACS Med. Chem. Lett. 9(6), 563-568 (2018).

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Average Rating: 5 ★★★★★ (Based on Reviews and 37 reference(s) in Google Scholar.)

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