BSJ-04-132 |
| Catalog No.GC50614 |
BSJ-04-132 es un PROTAC conectado por ligandos para Cereblon y CDK. BSJ-04-132 es un degradador de CDK4 basado en ribociclib potente y selectivo (PROTAC), con IC50 de 50,6 nM y 30 nM para CDK4/D1 y CDK6/D1, respectivamente. BSJ-04-132 no induce la degradaciÓn de CDK6 e IKZF1/3. BSJ-04-132 tiene actividad anticancerÍgena.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2349356-39-2
Sample solution is provided at 25 µL, 10mM.
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Selective Cdk4 degrader. Degrades Cdk4 in Molt-4 cells, with no effect on Cdk6 levels. Displays cereblon-dependent degradation.
Jiang et al (2019) Development of dual and selective degraders of cyclin-dependent kinases 4 and 6. Angew.Chem.Int.Ed.Engl. 58 6321 PMID:30802347
Average Rating: 5 (Based on Reviews and 24 reference(s) in Google Scholar.)
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