CMP-5 |
| Catalog No.GC39665 |
CMP-5 es un inhibidor potente, especÍfico y selectivo de PRMT5, mientras que no muestra actividad contra las enzimas PRMT1, PRMT4 y PRMT7. CMP-5 bloquea selectivamente S2Me-H4R3 al inhibir la actividad de la metiltransferasa PRMT5 en las preparaciones de histonas. CMP-5 previene la transformaciÓn de linfocitos B impulsada por el virus de Epstein-Barr (EBV), pero no afecta a las células B normales.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 880813-42-3
Sample solution is provided at 25 µL, 10mM.
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CMP-5 is a potent, specific, and selective PRMT5 inhibitor, while displays no activity against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. CMP-5 prevents Epstein-Barr virus (EBV)-driven B-lymphocyte transformation but leaving normal B cells unaffected[1][2].
[1]. Alinari L, et al. Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation.Blood. 2015 Apr 16;125(16):2530-43. [2]. Webb LM, et al. PRMT5-Selective Inhibitors Suppress Inflammatory T Cell Responses and Experimental Autoimmune Encephalomyelitis. J Immunol. 2017 Feb 15;198(4):1439-1451.
Average Rating: 5 (Based on Reviews and 4 reference(s) in Google Scholar.)
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