Coenzyme A (lithium salt hydrate) (Synonyms: CoA) |
| Catalog No.GC47114 |
An essential cofactor in enzymatic acetyl transfer reactions
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Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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Coenzyme A (CoA) is an essential cofactor functioning as an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism.1 About 4% of cellular enzymes utilize CoA as a substrate. It is synthesized from pantothenic acid in a five-step process that requires ATP.2 The pantothenate kinase step of the CoA biosynthetic pathway has been identified as a target for the development of antibacterial compounds.3
1.Leonardi, R., Zhang, Y.M., Rock, C.O., et al.Coenzyme A: Back in actionProg. Lipid Res.44(2-3)125-153(2005) 2.Jackowski, S.Biosynthesis of pantothenic acid and coenzyme AEscherichia coli and Salmonella typhimurium: Cellular and molecular biology687-694(1996) 3.Begley, T.P., Kinsland, C., and Strauss, E.The biosynthesis of coenzyme A in bacteriaVitamins and Hormones61157-171(2001)
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