D[LEU4,LYS8]-VP TFA |
| Catalog No.GC61959 |
D[LEU4,LYS8]-VP TFA es un agonista selectivo del receptor V1b de vasopresina, con Kis de 0,16 nM, 0,52 nM y 0,1,38 nM para el receptor V1b de rata, ser humano y ratÓn, respectivamente.
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![D[LEU4,LYS8]-VP TFA Chemical Structure](/media/struct/GC6/GC61959.png "D[LEU4,LYS8]-VP TFA Chemical Structure")
Sample solution is provided at 25 µL, 10mM.
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D[LEU4,LYS8]-VP TFA is a selective agonist of vasopressin V1b receptor, with the Kis of 0.16 nM, 0.52 nM, and 0.1.38 nM for rat, human and mouse V1b receptor, respectively. D[LEU4,LYS8]-VP TFA has weak antidiuretic, vasopressor, and in vitro oxytocic activities[1][2].
References:
[1]. Ana P, et, al. Pharmacological and physiological characterization of d[Leu4, Lys8]vasopressin, the first V1b-selective agonist for rat vasopressin/oxytocin receptors. Endocrinology. 2007 Sep; 148(9): 4136-46.
[2]. Ana P, et, al. Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasopressin at positions 4 and 8. J Med Chem. 2007 Feb 22; 50(4): 835-47.
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