DPBQ |
| Catalog No.GC33384 |
DPBQ activa p53 y desencadena la apoptosis de una manera poliploide especÍfica, pero no inhibe la topoisomerasa ni se une al ADN. DPBQ provoca la expresiÓn y fosforilaciÓn de p53 y este efecto es especÍfico de las células tetraploides.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 7029-89-2
Sample solution is provided at 25 µL, 10mM.
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DPBQ is a p53 activator.
DPBQ elicits apoptosis and cell death and is selective for effects in 4N cells. DPBQ elicits expression and phosphorylation of p53 and this effect is specific to tetraploid cells. Knockdown of TP53 restores proliferation of tetraploid cells in the presence of DPBQ[1].
[1]. Choudhary A, et al. Identification of Selective Lead Compounds for Treatment of High-Ploidy Breast Cancer. Mol Cancer Ther. 2016 Jan;15(1):48-59.
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