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Inicio >> Signaling Pathways >> Chromatin/Epigenetics >> Protein Ser/Thr Phosphatases

Protein Ser/Thr Phosphatases

Protein Ser/Thr phosphatases, belonging to the superfamily of protein phosphatases, are a diverse group of phosphatases that catalyze dephosphorylation and specifically remove phosphate groups from phosphorylated Ser and Thr residues within their substrates. Protein Ser/Thr phosphatases are comprised of two distinct families of phosphatases, including PPP phosphatases and PPM (or PP2C-related) phosphatases, which are coded by two unrelated gene families but share remarkably similar architecture of catalytic domains. PPP family was initially divided into two classes, type-I phosphatases (PP1) and type-2 phosphatases (PP2) consisting of PP2A, PP2B and PP2C isoforms. Novel protein phosphatases, such as PP4, PP5, PP6 and PP7, are also included in PPP family. PPM family is comprised of a number of Mg2+-dependent phosphatases encoded by different genes, which are structurally related to PP2C.

Products for  Protein Ser/Thr Phosphatases

  1. Cat.No. Nombre del producto Información
  2. GC17344 Alexidine dihydrochloride An alkyl bis(biguanide) antiseptic Alexidine dihydrochloride Chemical Structure
  3. GC15974 bpV(HOpic) (potassium salt, technical grade)

    Bisperoxovanadium(HOpic)

     bpV(HOpic) (sal de potasio, grado técnico) es un inhibidor potente y selectivo de PTEN con una IC50 de 14 nM. bpV(HOpic) (potassium salt, technical grade) Chemical Structure
  4. GC17011 C2 Ceramide

    C2 Ceramide (d18:1/2:0)， C2 Ceramide ，Ceramide (d18:1/2:0)， Cer(18:1/2:0)，N-acetoyl-D-erythro-sphingosine

     A cell-permeable analog of naturally occurring ceramides C2 Ceramide Chemical Structure
  5. GC12082 Cantharidic Acid (sodium salt) PP1 and PP2A inhibitor Cantharidic Acid (sodium salt) Chemical Structure
  6. GC12891 CCT007093 CCT007093 es un inhibidor eficaz de la proteÍna fosfatasa 1D (PPM1D Wip1). La inhibiciÓn de Wip1 puede activar la vÍa mTORC1 y mejorar la proliferaciÓn de hepatocitos después de la hepatectomÍa. CCT007093 Chemical Structure
  7. GC15718 CID 2011756 An inhibitor of protein kinase D CID 2011756 Chemical Structure
  8. GC14024 DL-AP3 A metabotropic glutamate receptor antagonist DL-AP3 Chemical Structure
  9. GC14395 Fostriecin sodium salt A potent inhibitor of protein phosphatases 2A and 4 Fostriecin sodium salt Chemical Structure
  10. GC16117 INCA-6

    Triptycene-1,4-quinone

     A cell-permeant inhibitor of NFAT signaling INCA-6 Chemical Structure
  11. GC12189 LB-100 protein phosphatase 2A(PP2A)inhibitor LB-100 Chemical Structure
  12. GC17676 Nafamostat

    Inhibidor de serina proteasa de amplio espectro, inhibidor de la calicreína.

     Nafamostat Chemical Structure
  13. GC16290 Nafamostat hydrochloride El clorhidrato de nafamostat, un inhibidor sintético de la serina proteasa, es un anticoagulante. Nafamostat hydrochloride Chemical Structure
  14. GC14875 NSC 663284

    Cdc25 Phosphatase Inhibitor II, DA30031, SPS8I1

     NSC 663284 (DA-3003-1) es un inhibidor de fosfatasa de doble especificidad Cdc25 potente, permeable a las células e irreversible, tiene un IC50 para Cdc25B2 de 0,21 μM. NSC 663284 exhibe una cinética competitiva mixta frente a Cdc25A, Cdc25B(2) y Cdc25C con valores de Ki de 29, 95 y 89 nM, respectivamente. NSC 663284 inhibe NSD2 (IC50 de 170 nM) a través de una interacciÓn directa con el dominio catalÍtico SET (Kd de 370 nM). NSC 663284 Chemical Structure
  15. GC11561 NSC 95397

    Cdc25 Inhibitor IV, PTP Inhibitor XXIX

     NSC 95397 es un potente inhibidor selectivo de la fosfatasa de doble especificidad Cdc25 (Ki = 32 nM (Cdc25A), 96 nM (Cdc25B), 40 nM (Cdc25C); IC50 = 22,3 nM (Cdc25A humano), 56,9 nM (Cdc25C humano), 125 nM (Cdc25B)). NSC 95397 inhibe la proteÍna quinasa fosfatasa-1 (MKP-1) activada por mitÓgeno y suprime la proliferaciÓn e induce la apoptosis en las células de cÁncer de colon a través de la vÍa MKP-1 y ERK1/2. NSC 95397 Chemical Structure
  16. GC16958 Okadaic acid

    Un potente inhibidor de fosfatasas de proteínas.

     Okadaic acid Chemical Structure
  17. GC16900 PRL-3 Inhibitor

    BR-1,P0108,Phosphatase of Regenerating Liver 3 Inhibitor,PTP4A3 Inhibitor

     El inhibidor de PRL-3 es un potente inhibidor de PRL-3 con un IC50 de 0,9 μM. El inhibidor de PRL-3 muestra una invasiÓn reducida en el ensayo basado en células. PRL-3 Inhibitor Chemical Structure
  18. GC15120 PTP Inhibitor I

    α-Bromo-4-hydroxyacetophenone|2-Bromo-4'-hydroxyacetophenone|4-Hydroxyphenacyl bromide|Protein Tyrosine Phosphatase Inhibitor I|SHP-1 Inhibitor II

     Inhibidor de PTP I un inhibidor de PTP1B, con una Ki de 42 μM. PTP Inhibitor I Chemical Structure
  19. GC15804 PTP Inhibitor II

    α-Bromo-4’-methoxyacetophenone|ω-Bromo-4’-methoxyacetophenone|4-(Bromoacetyl)anisole|4-Methoxyphenacyl bromide|NSC 129010|Protein Tyrosine Phosphatase Inhibitor II

     PTP Inhibitor II es un inhibidor de la proteÍna tirosina fosfatasa (PTP), con efecto antiangiogénico. PTP Inhibitor II Chemical Structure
  20. GC15969 PTP Inhibitor IV

    Protein Tyrosine Phosphatase Inhibitor IV

     PTP inhibitor PTP Inhibitor IV Chemical Structure
  21. GC13442 Sanguinarine chloride El cloruro de sanguinarina (Sanguinarin), un alcaloide de benzofenantridina derivado de la raÍz de Sanguinaria canadensis, puede estimular la apoptosis mediante la activaciÓn de la producciÓn de especies reactivas de oxÍgeno (ROS). La apoptosis inducida por sanguinarina estÁ asociada con la activaciÓn de JNK y NF-κB. Sanguinarine chloride Chemical Structure
  22. GC12498 Sephin1

    NSC 65390

     Sephin1 ((E/Z)-Sephin1) es un inhibidor selectivo de la subunidad reguladora de fosfatasa PPP1R15A (R15A). Sephin1 Chemical Structure
  23. GC11381 Tautomycetin Tautomycetin es un inhibidor potente y especÍfico de PP1 con actividad potencial inductora de apoptosis. Tautomycetin Chemical Structure
  24. GC11806 β-Glycerophosphate (sodium salt hydrate)

    Glycerol 2-Phosphate

    El β-glicerofosfato (sal de sodio hidratada) es un inhibidor de fosfatasa.

     β-Glycerophosphate (sodium salt hydrate) Chemical Structure

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