Foliglurax monohydrochloride (PXT002331 (monohydrochloride)) (Synonyms: PXT002331 (monohydrochloride)) |
| Catalog No.GC31077 |
El monoclorhidrato de foliglurax (PXT002331 (monoclorhidrato)) (PXT002331 monoclorhidrato) es un modulador alostérico positivo del receptor metabotrÓpico de glutamato 4 altamente selectivo y potente que penetra en el cerebro (mGluR4 PAM), con una EC50 de 79 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2133294-96-7
Sample solution is provided at 25 µL, 10mM.
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Foliglurax monohydrochloride (PXT002331 monohydrochloride) is a highly selective and potent, brain-penetrant mGluR4 positive allosteric modulator (PAM), with an EC50 of 79±19 nM[1]. Antiparkinsonian effect[1].
Foliglurax, a highly selective and potent mGlu4 receptor PAM with a marked brain-penetrance feature, might revolutionize the field of mGlu4 receptor drug targeting in CNS disorders[2].
[1]. Charvin D, et al. Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4. J Med Chem. 2017 Oct 26;60(20):8515-8537. [2]. Volpi C, et al. Opportunities and challenges in drug discovery targeting metabotropic glutamate receptor 4. Expert Opin Drug Discov. 2018 May;13(5):411-423.
Average Rating: 5 (Based on Reviews and 33 reference(s) in Google Scholar.)
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