E3 ligase Ligand 12 (Synonyms: E3 ligase Ligand 12) |
| Catalog No.GC35926 |
El ligando 12 de la ligasa E3 es el ligando IAP basado en el derivado LCL161. El ligando 12 de ligasa E3 se puede conectar al ligando ABL para proteÍna mediante un conector para formar SNIPER.
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Cas No.: 2095244-42-9
Sample solution is provided at 25 µL, 10mM.
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E3 ligase Ligand 12 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 12 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
[1]. Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575.
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