Glutaminyl Cyclase Inhibitor 3 |
Catalog No.GC36156 |
El inhibidor de glutaminil ciclasa 3 (compuesto 212), un compuesto anti-Alzheimer diseÑado, es un potente inhibidor de la glutaminil ciclasa humana (GC), con una IC50 de 4,5 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2092921-50-9
Sample solution is provided at 25 µL, 10mM.
Glutaminyl Cyclase Inhibitor 3 (compound 212 ), a designed anti-Alzheimer's compound, is a potent human Glutaminyl Cyclase (GC) inhibitor, with an IC50 of 4.5 nM. Glutaminyl Cyclase-IN-1 (compound 212) significantly reduced the brain concentrations of pyroform Aβ and total Aβ and restored cognitive functions[1]. IC50: 4.5 nM (hGC)[1].
[1]. Hoang VH, et al. Discovery of Potent Human Glutaminyl Cyclase Inhibitors as Anti-Alzheimer's Agents Based on Rational Design. J Med Chem. 2017 Mar 23;60(6):2573-2590.
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