Imrecoxib |
| Catalog No.GC36305 |
Imrecoxib (BAP-909) es un inhibidor novedoso y selectivo de la ciclooxigenasa 2 (COX-2) con un valor IC50 de 18 nM, también inhibe la actividad COX1- con un valor IC50 de 115 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 395683-14-4
Sample solution is provided at 25 µL, 10mM.
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Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 (COX-2) inhibitor with an IC50 value of 18 nM, it also inhibits COX1- activity with an IC50 value of 115 nM. Imrecoxib (BAP-909) has anti-inflammatory effect[1]. Human COX-1|115 nM (IC50)|Human COX-2|18 nM (IC50)
Imrecoxib (BAP-909) (0.1-10 µM; 24 hours) decreases COX-2 mRNA level induced by PMA+LPS at a dose dependent manner in U937 cells[1]. RT-PCR[1] Cell Line: U937 cells
Imrecoxib (BAP-909) (gastrointestinal administration; 5-20 mg/kg; 1 hour before carrageenan injection) inhibits carrageenan-induced acute inflammation, and the inhibitory effect is maximal at 4 hours[1].Imrecoxib (BAP-909) (gastrointestinal administration; 5-20 mg/kg; started on day 7; 26 days) diminishes the secondary paw swelling and inhibits heat-inactivated BCG induced-inflammtory polyarthritis[1]. Animal Model: Rat carrageenan-induced edema model[1]
[1]. Chen XH, et al. Imrecoxib: a novel and selective cyclooxygenase 2 inhibitor with anti-inflammatory effect. Acta Pharmacol Sin. 2004 Jul;25(7):927-31.
Average Rating: 5 (Based on Reviews and 35 reference(s) in Google Scholar.)
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