Kushenol A |
| Catalog No.GC36402 |
Kushenol A (Leachianone E) se aÍsla de la raÍz de Sophora flavescent. Kushenol A es un inhibidor de tirosinasa no competitivo para bloquear la conversiÓn de L-tirosina a L-DOPA, muestra valores de IC50 y Ki de 1.1 μM y 0.4 μM, respectivamente. Kushenol A es un antioxidante flavonoide, tiene efectos inhibitorios sobre la alfa-glucosidasa (IC50: 45 μM; Ki: 6,8 μM) y la β-amilasa. Kushenol A se confirma como un inhibidor potencial de las enzimas a las que se dirigen los cosméticos para el blanqueamiento y el envejecimiento de la piel.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 99217-63-7
Sample solution is provided at 25 µL, 10mM.
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Kushenol A is isolated from the root of Sophora flavescent, a non-competitive tyrosinase inhibitor with IC50 and Ki values of 1.1 μM and 0.4 μM, respectively[1].Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase and beta-amylase[2].Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging[1].
[1]. Kim JH, et al. Kushenol A and 8-prenylkaempferol, tyrosinase inhibitors, derived from Sophora flavescens. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1048-1054. [2]. Kim JH, et al. Glycosidase inhibitory flavonoids from Sophora flavescens. Biol Pharm Bull. 2006 Feb;29(2):302-5.
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