LX2761 |
Catalog No.GC36498 |
LX2761 es un inhibidor quÍmicamente estable y potente contra el cotransportador de glucosa dependiente de sodio 1 (SGLT1) y SGLT2 in vitro con IC50 de 2,2 nM y 2,7 nM para hSGLT1 y hSGLT2, pero muestra una inhibiciÓn especÍfica de SGLT1 en el tracto gastrointestinal (GI) .
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Cas No.: 1610954-97-6
Sample solution is provided at 25 µL, 10mM.
LX2761 is chemically stable and potent inhibitor against sodium-dependent glucose cotransporter 1 (SGLT1) and SGLT2 in vitro with IC50s of 2.2 nM and 2.7nM for hSGLT1 and hSGLT2, but displays specific SGLT1 inhibition in the gastrointestinal (GI) tract[1]. IC50: 2.2 nM (hSGLT1), 2.7nM (hSGLT2)[1]
[1]. Goodwin NC, et al. Discovery of LX2761, a Sodium-Dependent Glucose Cotransporter 1 (SGLT1) Inhibitor Restrictedto the Intestinal Lumen, for the Treatment of Diabetes. J Med Chem. 2017 Jan 26;60(2):710-721.
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