SNIPER(ER)-110 |
Catalog No.GC37657 |
SNIPER(ER)-110 consta de un ligando IAP y un ligando de estrÓgeno, conectados por un conector. SNIPER(ER)-51 induce la degradaciÓn de la proteÍna del receptor de estrÓgeno (ER) con DC50 de <3 nM y 7,7 nM después de 4 h y 48 h, respectivamente.
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Cas No.: 2241690-03-7
Sample solution is provided at 25 µL, 10mM.
SNIPER(ER)-110 consists of a cIAP1 ligand and an estrogen ligand, connected by a linker. SNIPER(ER)-51 induces estrogen receptor (ER) protein degradation with DC50s of <3 nM and 7.7 nM after 4 h and 48 h, respectively[1].
[1]. Ohoka N, et al. Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation. J Biol Chem. 2018 May 4;293(18):6776-6790.
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