APX-115 free base (Synonyms: Ewha-18278 free base) |
Catalog No.GC38115 |
La base libre APX-115 (base libre Ewha-18278) es un potente inhibidor de la pan NADPH oxidasa (Nox) activo por vÍa oral con valores Ki de 1,08 μM, 0,57 μM y 0,63 μM para Nox1, Nox2 y Nox4, respectivamente.
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Cas No.: 1270084-92-8
Sample solution is provided at 25 µL, 10mM.
APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base effectively prevents kidney injury[1].
[1]. Kwon G, et al. A novel pan-Nox inhibitor, APX-115, protects kidney injury in streptozotocin-induced diabetic mice: possible role of peroxisomal and mitochondrial biogenesis. Oncotarget. 2017 Jun 16;8(43):74217-74232.
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