Diphencyprone (Synonyms: Diphenylcyclopropenone, DPC, NSC 57541) |
Catalog No.GC45435 |
La difenciprona (Diphencyprone) es un agente inmunomodulador tÓpico que puede usarse para la investigaciÓn de la alopecia areata.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 886-38-4
Sample solution is provided at 25 µL, 10mM.
Diphencyprone (DCP) is a contact sensitizing agent.1,2,3 Pretreatment with DCP reduces symptom severity in a mouse model of experimental autoimmune encephalomyelitis (EAE) induced by myelin basic protein (1-10) (MBP1-10).1 It enhances IL-10 production and antigen-specific IgG2a antibody responses and reduces anaphylaxis and asthma induced by ovalbumin in mice when administered during ovalbumin immunization at a concentration of 1% v/v.2 Topical administration of DCP increases intrafollicular CD4+ and CD8+ T cells, reduces upper dermal inflammation, and stimulates hair growth in the C3H/HeJ mouse model of alopecia areta.3 Formulations containing DCP have been used in the treatment of alopecia areta.
References
1. Meister, M., Tounsi, A., Gaffal, E., et al. Self-antigen presentation by keratinocytes in the inflamed adult skin modulates T-cell auto-reactivity. J. Invest. Dermatol. 135(8), 1996-2004 (2015).
2. von Moos, S., Johansen, P., Waeckerle-Men, Y., et al. The contact sensitizer diphenylcyclopropenone has adjuvant properties in mice and potential application in epicutaneous immunotherapy. Allergy 67(5), 638-646 (2012).
3. Shapiro, J., Sundberg, J.P., Bissonnette, R.P., et al. Alopecia areata-like hair loss in C3H/HeJ mice and DEBR rats can be reversed using topical diphencyprone. J. Investig. Dermatol. Symp. Proc. 4(3), 239 (1999).
Average Rating: 5
(Based on Reviews and 30 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *